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-synuclein, and that is a primary part of Lewy bodies, in PARK 1 in 1997 and parkin in PARK 2 in 1998, that is an E3 ubiquitin ligase and triggers endoplasmic reticulum (ER) pressure, suggest that dysfunction on the intracellular proteinase units, like ubiquitin-proteasome technique or lysosomal program, which eliminates avoidable toxic proteins in… Read More

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